In-vitro activity of ofloxacin, levofloxacin and D-ofloxacin against staphylococci
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In-vitro activity of ofloxacin, levofloxacin and D-ofloxacin against staphylococci.
The in-vitro activity of levofloxacin was compared with ofloxacin and D-ofloxacin against 130 isolates of Staphylococcus aureaus and 117 isolates of coagulase-negative staphylococci, using the agar dilution method. In general, levofloxacin was equally active or up to fourfold more active than ofloxacin against all staphylococci, including 61 methicillin-resistant S. aureus. In contrast, D-oflox...
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The bactericidal activity of levofloxacin was compared with that of four other quinolones and one cephalosporin against four strains of Streptococcus pneumoniae with varying degrees of penicillin G susceptibility. Levofloxacin was found to be the most bactericidal quinolone at its optimum bactericidal concentration, followed by ofloxacin, ciprofloxacin, sparfloxacin and D-ofloxacin, in that ord...
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The antibacterial activity of levofloxacin was compared with those of ofloxacin, ciprofloxacin, and other antibiotics. In general, levofloxacin was equally active or up to fourfold more active than ofloxacin against all 801 organisms tested. Levofloxacin was twofold [corrected] more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin agains...
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Tuberculosis remains one of the main problem worldwide and the emergence of MDR-M.tuberculosis strains has become a major concern.The decreased activity of first line drugs,especially to isoniazid and rifampin causes some problems in the treatment of MDR-tb. Compared with the other infections,drugs clinically active to M.tuberculosis relatively more fewer (1). Because of this reason alternative...
متن کاملActivity of ofloxacin and pefloxacin against Mycobacterium leprae in mice.
The fluorinated quinolones are potent antibacterial compounds active against both gram-negative and gram-positive bacteria (1, 3-5, 11-13). Some are also active against mycobacteria in general (3, 9, 10, 13) and Mycobacterium tuberculosis in particular (1; unpublished observations). In view of the limited number of drugs active against Mycobacterium leprae, it was of interest to test some of th...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1996
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/38.2.259